解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Drug delivery into immune cells has high potential for the treatment of all kinds of inflammation, allowing a target-oriented transport of active agents. The advantage of this local drug release is the prevention of negative effects of systemic applications and low-dose application. Thereby, the phagocytotic capabilit...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9213-4
更新日期:2011-04-01 00:00:00
abstract::To investigate patients with severe acute pancreatitis (SAP) by dynamic levels of pro-/anti-inflammatory cytokines and endotoxin (ET) in plasma and the relationship between immunity and infection, organ dysfunction. Seventy-two patients with SAP were recruited. The ET, tumor necrosis factor-α (TNF-α), interleukin-6 (I...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9205-4
更新日期:2011-02-01 00:00:00
abstract::Cardiovascular diseases, including acute coronary syndrome (ACS), are the leading cause of death among humans. Adhesion proteins, owing to their involvement in the initiation and progression of atherosclerotic lesions, contribute to the progression of coronary disease and ACS occurrence. Considering ambiguosity of res...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9198-z
更新日期:2010-12-01 00:00:00
abstract::Valnemulin reportedly regulates inflammatory responses in addition to its in vitro antibacterial activity. In this study, we established a mouse model of lipopolysaccharide (LPS)-induced inflammatory lung injury and investigated the effect of valnemulin (100 mg/kg) on acute lung injury (ALI) 8 h after LPS challenge. W...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9186-3
更新日期:2010-10-01 00:00:00
abstract::This study was performed to evaluate the effects of epigallocatechin 3 gallate (EGCG) on lipopolysaccharide (LPS)-induced acute lung injury in a murine model. In the present study, production of TNF-alpha and MIP-2 and activation of extracellular signal-regulated kinases (ERK)1/2, c-Jun amino terminal kinases (JNK) an...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9161-z
更新日期:2010-04-01 00:00:00
abstract::Ruta graveolens L. (Rutaceae) are traditionally used for the treatment of rheumatism, arthritis and other inflammatory conditions in the traditional medicine of India, were evaluated for their protective effect in acute and chronic models of inflammation. Carrageenan induced rat paw edema and adjuvant induced arthriti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9154-y
更新日期:2010-02-01 00:00:00
abstract::Alveolar macrophages (AM) are the primary target cell of the lung for inhaled mycobacterial pathogens. We investigated the effect of the synthetic lipopeptide MALP-2 on the interaction between AM from rats and Mycobacterium bovis BCG. AM were infected with M. bovis BCG at a multiplicity of infection (MOI) of 10 and th...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9127-1
更新日期:2009-08-01 00:00:00
abstract::It has been well established that diet high in cholesterol and saturated fatty acids could significantly elevate plasma cholesterol levels and also increase the risk of cardiovascular diseases. We hypothesize that repeated systemic Escherichia coli (E. coli) in conjunction with hypercholesterolemia, leads to developme...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9107-5
更新日期:2009-04-01 00:00:00
abstract::To study the efficacy and mechanism of Salvia miltiorrhizae injection in the treatment of severe acute pancreatitis. SAP rat models were prepared and randomly divided into model control group and treated group. The sham-operated group was also set. At 3, 6 and 12 h after operation, the mortality rate, ascitic volumes,...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9109-3
更新日期:2009-04-01 00:00:00
abstract::To evaluate the role of ALA treatment on the healing of acetic acid-induced gastric ulcer, rats were given ALA (35 mg/kg/day) or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days (early) or 10 days (late) until they were decapitated. Gastric ulcer index, microscopic...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9100-4
更新日期:2009-02-01 00:00:00
abstract::The present study aimed at characterizing the phenotype and functions of adherent synovial fluid (SF) cells derived from rheumatoid arthritis (RA), comparing with fibroblast-like synoviocytes (FLS) derived from RA synovial tissue (ST). Adherent SF-derived cells were spindle-shaped from passages 1-6 under light microsc...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9087-x
更新日期:2008-12-01 00:00:00
abstract::Calgranulins are small calcium-binding proteins with several immunological functions involved in inflammatory processes. Calgranulin A is reported to be mainly associated with acute inflammation while calgranulin B seems to play a role in chronic inflammatory disorders. In this study we used a proteomic approach to an...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9085-z
更新日期:2008-10-01 00:00:00
abstract::To investigate the role of glutathione (GSH) synthesis in the regulation on nuclear factor (NF)-kappaB activity and tumor necrosis factor-alpha (TNF-alpha) release by glutamine (GLN) in lipopolysaccharide (LPS)-stimulated alveolar type II (AT-II) epithelial cells of rat lungs. Primary cultured AT-II cells were pre-tre...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9084-0
更新日期:2008-10-01 00:00:00
abstract::We compared exhaled breath condensate (EBC) and induced sputum (IS) for assessing inflammation in pulmonary diseases in patients with obstructive lung disease (n = 20), persistent cough >6 months (n = 20), interstitial lung disease (n = 25) and controls (n = 10). EBC was collected by suspending a Teflon perfluoroalkox...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-007-9020-8
更新日期:2007-04-01 00:00:00
abstract::Previous studies have suggested that Interleukin-6 (IL-6) acts as a marker of vasculitis. To determine the role of IL-6 in vasculitis we utilized two models of immune complex induced vascular injury (dermal Arthus and acute pulmonary alveolitis) in IL-6 deficient (IL-6(-/-)) and IL-6 sufficient (IL-6(+/+)) mice. Plasm...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-006-9011-1
更新日期:2005-12-01 00:00:00
abstract::The widely used mouse air pouch model of acute inflammation is inducible in a variety of inbred strains, but the potential influence of genetic background and gender on inflammation severity has never been examined. We directly compared the degree of inflammation induced in the air pouch model across four commonly uti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-006-8962-6
更新日期:2005-02-01 00:00:00
abstract::Numerous cytokines, including vascular endothelial growth factor (VEGF), are implicated in the pathogenesis of sepsis. While overexpression of VEGF produces pulmonary capillary leak, the role of VEGF in sepsis is less clear. We investigated VEGF in sepsis, utilizing a VEGF trap (VEGF(T)). Polymicrobial sepsis was indu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-004-6050-3
更新日期:2004-10-01 00:00:00
abstract::Several experiments have detected that melatonin exerts a marked influence on the inflammatory process. In the present study we evaluated the effect of exogenous melatonin on the experimental granulomatous tissues in rat. Our data show that subcutaneous administration of different doses of melatonin given daily during...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000049043.89586.89
更新日期:2004-08-01 00:00:00
abstract::Sublethal doses of LPS result in increased tolerance to high concentrations of oxygen and this is associated with decreased pulmonary inflammation in a rat model. To investigate the mechanism of decreased neutrophil influx into the lung in this model, we measured levels of mRNA in the lung for the endothelial adhesion...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000039561.37868.91
更新日期:2004-06-01 00:00:00
abstract::Myeloperoxidase (MPO), next to the NO synthase2 (NOS2), and NADPH oxidase, is the key enzyme of the oxidative burst responsible for the antimicrobial immunity. Because MPO participates in the eradication of Mycobacterium tuberculosis in the in vitro model and the extracellular enzyme may activate cells to cytokine syn...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000033020.28446.a6
更新日期:2004-04-01 00:00:00
abstract::Gram-positive and Gram-negative bacteria induce different cytokine patterns in human mononuclear cells. We have seen that Gram-positives preferentially induce IL-12 and TNF-alpha, whereas Gram-negatives induce more IL-10, IL-6, and IL-8. In this study, we compared the capacity of these two groups of bacteria to induce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000006700.41614.21
更新日期:2003-12-01 00:00:00
abstract::We have characterized leukocyte migration to the pleural cavity in a methylated-BSA (mBSA)-induced model of murine delayed-type hypersensitivity and evaluated the ability of IL-4 and IL-10 to modulate this response. Neutrophils, macrophages, T cells, and dendritic cells migrated to the pleural cavity in a time-depende...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1025076111950
更新日期:2003-08-01 00:00:00
abstract::DBA/1LacJ mice were immunized with type II collagen and boosted with bacterial lipopolysaccharide (LPS) 17 days later to induce accelerated arthritis. Clinical signs of inflammation were observed as early as Day 20. Matrix metalloproteinases MMP-2, -3, -9, and -13, but not MMP-12, mRNA levels were increased on Day 24....
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1023282701505
更新日期:2003-04-01 00:00:00
abstract::Lipopolysaccharide (LPS) increases serum TNF-alpha levels due to TNF-alpha secretion by macrophages. The serum TNF-alpha response to LPS was augmented 10x when FcgammaR ligation was induced by the intravenous injection of Gig-coated erythrocytes (IgG) prior to the administration of LPS. The macrophage population respo...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1021468819285
更新日期:2002-12-01 00:00:00
abstract::The secretion of calcitonin gene-related peptide (CGRP) and the chemokines KC and MIP-2 are increased in the animal models of endotoxemic and septic shock. We tested whether CGRP could modulate KC and MIP-2 secretion from different sources of macrophages after murine sepsis induced by cecal ligation and puncture (CLP)...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1016515712344
更新日期:2002-08-01 00:00:00
abstract::NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to what effects these agents have on the progression of OA. In vitro studies showed several types of NSAIDs (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of NSAIDs (e.g., ...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1023/a:1015504632021
更新日期:2002-06-01 00:00:00
abstract::Current knowledge implicates pleural mesothelial cells as mainly responsible for inflammatory responses in the pleural space. However, a vast body of recent evidence underscores the important role of fibroblasts in the process of inflammation in several types of tissues. We hypothesize that HPFBs (human pleural fibrob...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1014884127573
更新日期:2002-04-01 00:00:00
abstract::Free radicals play an important role in the initiation and progression of inflammatory bowel disease (IBD). Therefore, the reduction or elimination of adverse oxidant effects can provide novel therapy for IBD. Here, the antioxidant capacity and protective effects of a new class of chemically modified hetastarch (polyn...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1014420327417
更新日期:2002-02-01 00:00:00
abstract::Effects of several cytokines on kinetics of Intercellular Adhesion Molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1) expression were studied on a bronchial epithelial cell line (BEAS-2B). VCAM-I was neither constitutively expressed on BEAS-2B cells nor induced by Interferon-gamma (IFN-gamma). Tumor Ne...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1012850630351
更新日期:2001-12-01 00:00:00
abstract::We analyzed the influence of heparins (unfractionated heparin, UFH and low molecular weight heparin certoparin) on the generation of IL-1ra, IL-6, IL-10, and IL-12p40 and from leukocyte fractions in vitro. Polymorphonuclear neutrophil leukocytes (PMN) and peripheral blood mononuclear cells (PBMC) from 16 different hea...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1012883916991
更新日期:2001-10-01 00:00:00
abstract::Interactions of macrophages with epithelium represent one of the pathways involved in regulating local immune mechanisms. We studied the effect of cell-cell contact with an epithelial monolayer on the phenotype of macrophages. Human monocytes and THP-1 macrophages were co-cultured with monolayers of human bronchial ep...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1010975804179
更新日期:2001-08-01 00:00:00
abstract::To determine the effect of heat stress on histopathology of acute lung injury (ALI) caused by administration of lipopolysaccharide (LPS), and to determine the roles of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, interferon (IFN)-gamma, IL-10 and surfactants in heat-induced tolerance to ALI, we administe...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1011040515262
更新日期:2001-06-01 00:00:00
abstract::The intracellular signaling pathways involved in human monocyte chemotaxis toward a variety of chemoattractant molecules were evaluated using selected pharmacological agents. Neither phosphatidylinositol-3-kinase (P13K) or extracellular signal-regulated kinase (ERK) activity were required for monocyte migration toward...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1007152903135
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Accumulation of immune complexes in the mesangium is a common finding. Since migration of macrophages (Mphi) in the mesangium has been demonstrated to be an important event in the development of glomerular lesions, we studied the role of immune complexes and mesangial cell (MC) interaction in the transmigrat...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1007073306394
更新日期:2000-12-01 00:00:00
abstract::We have previously reported the antifibrotic effects of pirfenidone (PD) in the bleomycin (BL)-hamster model of lung fibrosis. Since the development of fibrosis is generally preceded by acute lung inflammation, the present study was conducted to find out if dietary intake of PD (0.5%) has any effects on BL-induced lun...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1007068313370
更新日期:2000-10-01 00:00:00
abstract::Interferon gamma (IFNγ)-mediated activation of the myelomonocytic cell line HL-60 and peripheral blood monocytes will induce expression of an epitope for the monoclonal antibody which recognizes human αEβ7 integrin, HML-1. Here, we found that the anti-human αEβ7 monoclonal antibody Ber-ACT8 did not recognize IFNγ-stim...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1007007428255
更新日期:2000-06-01 00:00:00
abstract::An inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been implicated in the pathogenesis of inflammatory lung diseases such as interstitial pneumonia (IP). To clarify the role of the inflammatory cytokine in the pathogenesis of lung inflammation, we introduced a murine TNF-alpha gene into murine lungs by t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1006992408052
更新日期:2000-02-01 00:00:00
abstract::The diabetic organism is unable to produce normal amount of granulation tissue which results in delayed wound healing, a significant clinical problem. In the present study, the effect of oral administration of aminoguanidine (AG), in the diabetes-induced inhibition of angiogenesis and granulation tissue formation was ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020246624605
更新日期:1999-12-01 00:00:00
abstract::The effects of an intravenous injection (i.v.) of Sephadex beads (20 mg kg(-1)) were examined on bronchial responsiveness to ACh (1-200 microg kg(-1) i.v.) as well as on cell accumulation in guinea-pig lung. Bronchial hyperreactivity to ACh, measured as increase in pulmonary insufflation pressure (PIP), was observed 3...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1021913009742
更新日期:1999-10-01 00:00:00
abstract::The newly discovered gamma-PKC-related-protein of human leukocytes (gamma-rp) crossreacts with a polyclonal antibody preparation originally designed to be specific for PKC-gamma (gammaMb-Ab). As this antibody is currently the only suitable probe for gamma-rp, we sought to characterize the binding of the two proteins. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020265701407
更新日期:1999-08-01 00:00:00